| Date | Opponent | Location | Time/Score | |
|---|---|---|---|---|
| 2/18/2022 | Clemson | Clemson, SC |
L 0-9 |
|
| 2/19/2022 | Clemson | Clemson, SC | L 4-19 | |
| 2/20/2022 | Clemson | Clemson, SC | L 4-5 | |
| 2/22/2022 | Miami (Ohio) | Oxford, OH | postponed | |
| 2/25/2022 | Arkansas | Round Rock, TX | L 2-5 | |
| 2/26/2022 | Louisana | Round Rock, TX | W 12-4 | |
| 2/27/2022 | Stanford | Round Rock, TX | L 0-13 | |
| 3/1/2022 | Miami (Ohio) | Bloomington, IN | W 15-2 | |
| 3/4/2022 | Missouri State | Springfield, MO | L 7-9
|
|
| 3/5/2022 | Missouri State | Springfield, MO | W 12-3 | |
| Missouri State | Springfield, MO | W 10-4 | ||
| Cincinnati | Bloomington, IN | W 7-0 | ||
| Purdue Fort Wayne | Bloomington, IN | W 12-2 | ||
| Troy | Troy, AL | L 1-2 | ||
| 3/12/2022 | Troy | Troy, AL |
L 4-6 |
|
| 3/13/2022 | Troy | Troy, AL | L 4-7 | |
| 3/15/2022 | Kentucky | Bloomington, IN | W 20-7 | |
| Xavier | Bloomington, IN | L 7-9 | ||
| Xavier | Bloomington, IN | L 10-12 | ||
| 3/20/2022 | Xavier | Bloomington, IN | W 13-3 | |
| 3/20/2022 | Xavier | Bloomington, IN | L 7-13 | |
| Indiana State | Bloomington, IN | Postponed | ||
| Evansville | Bloomington, IN | L 14-17 | ||
| Evansville | Bloomington, IN | W 6-5 | ||
| Evansville | Bloomington, IN | W 6-5 | ||
| Northwestern | Bloomington, IN | W 5-4 | ||
| Northwestern | Bloomington, IN | L 6-7 | ||
| Northwestern | Bloomington, IN | L 6-13 | ||
| Evansville | Evansville, IN | L 4-8 | ||
| Purdue | West Lafayette, IN | L 0-17 | ||
| 4/10/2022 | Purdue | West Lafayette, IN | W 10-3 | |
| 4/10/2022 | Purdue | West Lafayette, IN | L 15-16 | |
| 4/12/2022 | Indiana State | Terre Haute, IN | W 6-5 | |
| 4/15/2022 | Rutgers | Piscataway, NJ | L 3-5 | |
| 4/16/2022 | Rutgers | Piscataway, NJ | L 2-4 | |
| Rutgers | Piscataway, NJ | L 9-10 | ||
| 4/19/2022 | Miami (Ohio) | Oxford, OH | L 7-9 | |
| Cincinnati | Cincinnati, OH | W 11-4 | ||
| 4/22/2022 | Nebraska | Bloomington, IN | W 8-7 | |
| Nebraska | Bloomington, IN | W 8-1 | ||
| Nebraska | Bloomington, IN | L 7-19 | ||
| Butler | Indianapolis, IN | W 9-1 | ||
| 4/27/2022 | Illinois State | Normal, IL | W 3-1 | |
| 4/29/2022 | Illinois | Bloomington, IN | W 7-6 | |
| 4/30/2022 | Illinois | Bloomington, IN | L 10-18 | |
| 5/1/2022 | Illinois | Bloomington, IN | W 11-7 | |
| 5/6/2022 | Michigan | Ann Arbor, MI | L 4-8 | |
| 5/7/2022 | Michigan | Ann Arbor, MI | W 9-5 | |
| 5/8/2022 | Michigan | Ann Arbor, MI | W 10-8 | |
| 5/10/2022 | Louisville | Louisville, KY | L 2-7 | |
| 5/13/2022 | Minnesota | Bloomington, IN | W 8-6 | |
| 5/14/2022 | Minnesota | Bloomington, IN | W 12-0 | |
| 5/15/2022 | Minnesota | Bloomington, IN | L 8-9 | |
| 5/17/2022 | Illinois State | Bloomington, IN | W 12-7 | |
| 5/19/2022 | Iowa | Iowa City, Iowa | L 16-30 | |
| 5/20/2022 | Iowa | Iowa City, Iowa | 7 p.m | |
| 5/21/2022 | Iowa | Iowa City, Iowa | 9 p.m | |
| 5/25/2022 | Maryland | Omaha, NE | 5 p.m. | |
| 5/26/2022 | tba | Omaha, NE | 1 p.m. |
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